That said, the in vitro experiments in this and previous studies have demonstrated the potential for anti-DENV antibodies to promote subsequent ZIKV infection of FcγR-bearing cell lines in vitro, but the inability of this phenomenon to translate to increased ZIKV titers in the biofluids of an otherwise relevant in vivo model is of key importance in order to inform the approach to large scale clinical studies in flavivirus endemic human populations. Here, FCGR2A is linked to Zika virus infectious disease.