HHT and HT are homologs with differences only in the ester group (Fig 2) [22, 24] that have been widely used to treat various leukemia types, such as chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [19]. Here, ACVRL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.