In particular, we focused on three categories of genes: 1) known exercise-responsive genes (Pgc1a, Il6, Nr4a1, Nr4a2 and Nr4a3); 2) myogenic and muscle regeneration-related genes (Myf5, Myogenin, Myomaker and Myh3); and 3) Gpr56 and its ligand Col3a1. In the present study, we also investigated whether diabetes could induce exercise-induced transcriptional alterations, by comparing the data obtained from the two PAD mouse models. Here, IL6 is linked to peripheral arterial disease.