Diabetic KK-Ay PAD mice showed exercise-induced acute upregulation of Pgc1a, Il6, Nr4a1, Nr4a2, Nr4a3, and Gpr56, similar to that observed in non-diabetic C57BL/6 PAD mice (Figs 2 and 4). The gene discussed is PPARGC1A; the disease is peripheral arterial disease.