SERPINE1 and diabetes mellitus: In fully adjusted models, comparison of the 75th to the 25th percentile (14.3 vs. 5.1 μg/g creatinine) of baseline urine arsenic was not significantly associated with Visit 2 PAI-1 when stratifying in those with or without diabetes (GMR without diabetes: 0.94, 95% CI: 0.87, 1.01; GMR with diabetes: 0.95, 95% CI: 0.89, 1.01) and there was no significant difference in the association between arsenic and PAI-1 by diabetes status (p-interaction = 0.66) (Table 3, Model 2; Fig 1).