Most of the necrotic areas over-expressed CD14, which may have been due to tumor cells being hypoxic when tumor angiogenesis was insufficient to maintain the growth of tumor cells, thus inducing tumor cells to secrete a series of inflammatory mediators and chemokines and causing microglia to gather around the tumor and mononuclear cells in the blood to migrate to the tumor site through the damaged blood-brain barrier. Here, CD14 is linked to neoplasm.