This study used samples and outcome data from the Fragmin and Fast Revascularization during Instability in Coronary Artery Disease (FRISC-II) study conducted in the late ‘90s, used a third generation Troponin assay and showed a significant interaction between GDF-15 levels and the effect of treatment strategy on the recurrent MI. This evidence concerns the gene GDF15 and myocardial infarction.