While studies using proteomics techniques have identified a number of additional AD candidates (e.g., neuronal pentraxin receptor (NPTXR) and heart-type fatty acid binding protein (FABPH) [23–28]), many of these studies have been done on small cohorts [25,29] involving small arrays of CSF markers, using less powerful computational approaches and did not validate the markers in an independent cohort. This evidence concerns the gene NPTXR and Alzheimer disease.