MAPT and Alzheimer disease: While similar analysis using combinations of Aβ42, t-tau and p-tau (181) to place the MCI subjects into signature positive and negative groups at baseline reveal faster progression of the signature positive MCI subjects to AD (MTP of 25.69 versus 48.89 months, p = 0.0065, hazard ratio = 1.92, Fig 4B), the 16-peptide signature provided a more robust predictor of MTP (Table 7).