HSPA5 and obesity due to melanocortin 4 receptor deficiency: To determine if the hypertrophy and inflammation noted in visceral adipose was accompanied by cell injury, adipocyte injury in visceral adipose of NOX2-FL and mNOX2-KO mice was estimated by evaluating the expression GADD153/CHOP and GRP78, both of which are known to be increased in the context of obesity and thought to reflect inflammation-induced endoplasmic reticulum (ER) stress [26].