LMO2 and SPIB transcriptional repression and XBP-1 activation were followed during the first 30 days after infection of primary CD19+ve B cells with the 3A3CERT2 virus +/- HT, and were found to be consistent with BLIMP-1 activation and comparable to the phenotype seen after infection with EBNA3KO virus relative to ‘WT’ (B95.8-BAC) infection (S5 Fig). This evidence concerns the gene XBP1 and infection.