In particular, BLIMP-1 mRNA expression after infection with recombinants in which both EBNA3A and EBNA3C were inactivated (3A3CERT2 -HT) were greatly increased (Fig 4C and 4F), similar to p18INK4c mRNA (compare Figs 3F and 4F) and comparable to the results using EBNA3KO virus (Fig 4G). The gene discussed is CDKN2C; the disease is infection.