TGFB1 and diabetes mellitus: A recent study confirmed that FGF/FGFR suppressed TGFβ-induced EndMT via the induction of miR-let-7s.25 Our previous study also demonstrated that AcSDKP restored diabetes-suppressed FGFR and FGFR phosphorylation levels.22 FGFR1 has been confirmed as a key inhibitor of TGFβ-induced EndMT.26 Here, we established the FGFR1 signaling-dependent inhibitory effects of AcSDKP on TGFβ/smad signaling and EndMT in HMVECs (Figure 8).