The activities of C-Myc and aldehyde dehydrogenase 1 (Aldh1) have been used to define enhanced tumorigenesis and stem cell properties of cancers.29, 30 Upon UEV1A induction, cellular C-Myc and Aldh1 levels were also markedly reduced (Figure 4b and Supplementary Figures S3a and c). This evidence concerns the gene UBE2V1 and cancer.