CDK4 and neoplasm: As the first step toward understanding the role of UEV1A in tumor inhibition, we examined the effects of UEV1A overexpression on several oncogenes known to be highly expressed in OS cells.28 Compared with the control, Dox-induced UEV1A reduced MYC and CDK4 expression by >50% (Figures 4a and b and Supplementary Figure S3a) and this effect appears to be specific for UEV1A, as ectopic expression of UEV1C, MMS2 or UBC13 did not cause such consistent reduction (Figure 4a).