In our previous studies, immunohistochemical (IHC) analyses of human chondrosarcoma tissue have shown that levels of BDNF and VEGF-C expression are highly correlated with tumor stage.3, 18 Here, we further demonstrated that BDNF expression was strongly correlated with VEGF-C expression in human chondrosarcoma specimens (Figure 6e). This evidence concerns the gene BDNF and chondrosarcoma.