For example, Ras is capable of activating the PI3K/AKT/mTOR pathway in addition to the Raf/MEK/ERK pathway, whereas ERK can activate mTOR signaling.24 Interestingly, the AKT/mTOR and MEK/ERK pathways are known to be activated in some sarcoma subtypes.34, 35, 36 However, the mechanism underlying signal transduction between MEK, ERK and mTOR signaling in chondrosarcoma remains unclear. This evidence concerns the gene MAP2K7 and sarcoma.