BDNF has been considered to be an important factor during carcinogenesis.39 BDNF serves as a poor prognostic factor and facilitates tumor progression, but its precise role in tumor lymphangiogenesis has largely remained unknown.40 In this study, the mRNA data demonstrate significantly higher BDNF and VEGF-C expression in chondrosarcoma patients compared with that in healthy individuals. This evidence concerns the gene BDNF and chondrosarcoma.