Our previous studies have shown that BDNF is associated with chondrosarcoma metastasis and angiogenesis.16, 17, 18 VEGF-C has been reported to mediate tumor lymphangiogenesis in many human cancers.19, 20 However, the effect of BDNF on VEGF-C expression and lymphangiogenesis in chondrosarcoma has not been well explored. This evidence concerns the gene BDNF and cancer.