Our previous studies have demonstrated that lymphangiogenesis is one of the major routes for tumor invasion and metastasis in chondrosarcoma.3, 29 VEGF-C is a key modulator in tumor lymphangiogenesis and metastasis, so is therefore a potential target for preventing lymphatic metastasis.2 Here, we provide novel insights into the role of BDNF in tumor-associated lymphangiogenesis. The gene discussed is BDNF; the disease is chondrosarcoma.