We showed that (1) both FUT5 and FUT6 were highly expressed in CRC tissues and cell lines, which enhanced the proliferation, migration, invasion and angiogenesis capacity of CRC cells and tumour growth in vivo, and (2) miR-125a-3p was significantly downregulated in CRC tissues and cell lines, as miR-125a-3p expression could greatly inhibit migration, invasion and angiogenesis of CRC cells and tumour growth in vivo, further improving survival. Here, FUT5 is linked to colorectal carcinoma.