The PI3K/Akt pathway has a critical role in most of the hallmark properties of cancer, including proliferation, tumourigenesis, tumour growth and angiogenesis.24, 25 Several reports highlight that aberrant activation of PI3K-AKT can promote cancer invasion and metastasis in many tumours, including CRC.26, 27 Numerous negative regulators, including regulatory proteins and miRNAs, inhibit the PI3K/Akt pathway and function as tumour suppressors in CRC.28 However, little is known regarding the effects of the miR-125a-3p/FUT5-FUT6 axis on the PI3K/Akt pathway in CRC. Here, FUT6 is linked to cancer.