SERPINF1 and neoplasm: After 4 weeks, PEDF-overexpressing cells formed larger tumors than control group (P<0.05; Supplementary Figure 3a), consistent with previous reports.14 Histological examinations of liver and lung tissues indicated that PEDF-overexpressing tumor-bearing mice had more intrahepatic metastatic nodules than control mice (P<0.01; Figures 2c and d).