LR has an important role in various cancer types, where it contributes to invasion, apoptosis evasion and adhesion.24, 31 To test the hypothesis that LR might have a role in the PEDF-induced facilitation of HCC cell migration and invasion, we first investigated whether LR can affect the migration and invasion of HCC cells. The gene discussed is SERPINF1; the disease is hepatocellular carcinoma.