Notably, the median OS time was 34.90 (95% CI: 21.32–48.49) months for HCC patients with high expression of PEDF alone, whereas it was 27.67 (95% CI: 20.26–35.08) months for HCC patients with high expression of PEDF and positive expression of LR and 30.93 (95% CI: 23.40–38.46) months for HCC patients with high expression of both PEDF and N-cadherin. The gene discussed is SERPINF1; the disease is hepatocellular carcinoma.