Transwell assays demonstrated that PEDF overexpression significantly enhanced both the migration and invasion of SMMC-7721, HCC-LY5 and PLC/PRF/5 cells (Figure 2a), whereas silencing PEDF markedly inhibited both the migration and invasion of Huh7 and MHCC-97L cells (Figure 2b and Supplementary Figure 2a). Here, SERPINF1 is linked to hepatocellular carcinoma.