We and others have shown clinical relevance of miR-519a-3p and MICA/ULBP2 in breast cancer.29, 36 Although low levels of MICA and ULBP2 correlate with poor clinical outcome in breast cancer patients,36 miR-519a-3p is elevated in higher-grade breast cancer29 and correlates with reduced relapse-free survival (Supplementary Figures S14a and b). This evidence concerns the gene MICA and breast carcinoma.