TNFSF10 and breast cancer: Besides TRAIL and FasL, apoptosis can be induced by various stimuli and through diverse mechanisms.32, 39, 40 However, development of resistance toward apoptosis is one major clinical challenge.14, 21 Anthracyclines and taxanes have remained major first-line chemotherapies in treatment of metastatic luminal B and TNBC11 despite the development of acquired or de novo resistance in metastatic and high-grade breast cancer.41 Ajabnoor et al.42 showed that paclitaxel resistance is associated with diminished apoptotic response by loss of caspase-mediated cell death.