HPV-driven cancers of the cervix, head and neck, and penis share copy number alteration sites, most notably copy number gains in 3q, which in addition to PIK3CA contains the telomerase RNA component (TERC), MDS1 and EVI1 complex locus (MECOM), SRY-box 2 (SOX2), and TP63 genes [18,34,37,38]. Here, PIK3CA is linked to cervical cancer.