F-box and WD repeat domain containing 7 (FBXW7) is involved in angiogenesis through regulation of the Notch pathway [126] and is mutated at higher rates in cervix (11–15%) and HPV-positive head and neck (12%) squamous cell carcinomas than in combined head and neck squamous cell carcinomas (HPV status not specified) (5%) [18,35,36]. Here, FBXW7 is linked to head and neck squamous cell carcinoma.