Although fewer than 1% of cervical squamous cell carcinomas are HPV-negative, one study reported a difference in TP53 mutation status by classifying tumors in the TCGA-CESC data set as “HPV active” (expressing HPV transcripts; 4% TP53 mutation rate) versus “HPV inactive” (not expressing HPV transcripts; 47% TP53 mutation rate and 8% of the total number of HPV-positive samples) [80]. Here, TP53 is linked to cervical squamous cell carcinoma.