Both oncoproteins interfere with important cellular tumor suppressor pathways: E6 inhibits the p53 tumor suppressor by promoting its proteasomal degradation [26,27], while E7 disrupts the retinoblastoma (Rb) pathway resulting in uncontrolled activation of the cell cycle and induction of p16INK4A, a cyclin-dependent kinase inhibitor, through a disrupted feedback loop (Figure 1) [28,29,30]. Here, RB1 is linked to neoplasm.