However, several agents were proved efficient in cell lines, including plant extracts: moscatilin [285], fucoidan [286], quercetin [287], thymoquinone [288], imipramine blue [289] and finally, in vitro and in vivo data on NSCLC suggest a potential impact of the harmala alkaloids to downregulate TWIST1 [267]. The gene discussed is TWIST1; the disease is non-small cell lung carcinoma.