While using another model, i.e., radiation injury combined with severe sepsis in rats, ghrelin can interfere with the release of norepinephrine from the stimulated gut sympathetic fibers and, by this means, can induce a down-regulation of the pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) activated by norepinephrine [17]. The gene discussed is IL6; the disease is Sepsis.