GHRL and Sepsis: Thus, so far along with its other physiological effects such as (i) stimulation of growth hormone release from the anterior pituitary gland and hypothalamus; (ii) induction of a positive energy balance; (iii) stimulation of neurogenesis and neuroprotection against damage due to ischemia, traumatic brain injury and neuromediator excitotoxicity; and (iv) suppression of sepsis and protection of vascular endothelium against septic inflammation, ghrelin has been also demonstrated to sustain endothelial function and angiogenesis [17,24,25,26,27,28].