Likewise, plasma soluble intracellular adhesion molecule-1 (sICAM-1), soluble endothelial selectin (sE-selectin), myeloperoxidase (MPO) and active and total plasminogen activator inhibitor (PAI-1) were higher in children with obesity, whereas matrix metalloproteinase-9 (MMP-9) showed no differences between groups. This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.