LEPR and obesity due to melanocortin 4 receptor deficiency: We found no association between other previously described functional LEPR SNPs and obesity such as rs1137101 (Gln223Arg), which has been associated with lower and higher obesity risk in Spanish adults [16] and girls [29], respectively, but not in Turkish [24], Polish [25,30], Mexican Mestizo [26] or European [27] children and adolescents, as well as with type 2 diabetes [31].