Levels of another tumor suppressor miRNA, miR-150 (mentioned in Section 2.3.1), were also reduced in the NPM/ALK(+) ALCL cell lines and biopsy specimens as a consequence of DNA hypermethylation, with DNA hypermethylation-mediated miR-150 repression also shown to require ALK-dependent pathways [37]. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.