When analyzing the differences of miRNA regulation in ALK(+) versus ALK(−) cells following inactivation of STAT3 by shRNA-mediated ALK or STAT3 knockdown, miR-135b expression was most prominently altered, with a significant upregulation in ALK(+) ALCL cell lines and human primary ALK(+) ALCL samples compared to ALK(−) ALCL cells [30,43]. This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.