Moreover, C57BL/6 RAG2−/−γc−/− mice that lack not only T and B cells but also NK cells [93] produce reduced serum levels of IFNγ and develop enhanced bacterial burden and liver pathology in the infection with R. conorii compared to NK cell-competent C57BL/6 RAG2−/− mice [44]. The gene discussed is IFNG; the disease is infection.