However, while REMOVAL was under way, the Carotid Atherosclerosis: MEtformin for insulin ResistAnce (CAMERA) trial reported no impact of 18 months of metformin treatment on cIMT in individuals without diabetes but with established coronary heart disease [37], and the Copenhagen Insulin and Metformin Therapy (CIMT) trial reported no reduction in cIMT progression in insulin-treated people with type 2 diabetes [38]. Here, INS is linked to diabetes mellitus.