In accordance with this view, Cambier and colleagues demonstrated that high-affinity insulin-binding B cells are present in healthy individuals exclusively in the anergic naive compartment, while these insulin-binding B cells lose their anergic phenotype in individuals who are at risk of diabetes (TN01 participants) or who have new-onset (< 1 year) type 1 diabetes [26]. The gene discussed is INS; the disease is diabetes mellitus.