However, taking into account the fact that plasma concentration of MMP-2 was also elevated in the group of diabetic subjects with aspirin-HPR with respect to diabetics without aspirin-HPR and high on-aspirin treatment platelets reactivity did not increase plasma MMP-2 irrespective to diabetes mellitus, this suggests that coincidence of both DM and HPR may affect plasma level of MMP-2. This evidence concerns the gene MMP2 and diabetes mellitus.