EGFR and colorectal carcinoma: To determine whether differential EPCR expression is associated with altered chemotherapy or EGFR monoclonal antibody (cetuximab) responsiveness in CRC patients, immunohistochemistry for EPCR was performed on 153 CRC tumour samples from the MRC COIN study 23 and analysed using Definiens Tissue Studio software (see supplementary materials and methods).