YBX1 and neoplasm: In details, Somasekharan et al. showed that under stress condition, a YB1, nuclease-sensitive element-binding protein 1, facilitates tumor metastasis through two mechanisms: first, it directly binds to HIF1α that drives stress adaptation and metastatic capacity in vivo; second, YB1 mediates formation of cytosolic SGs through translational activation of G3BP1, a SG nucleator [159].