A further detailed analysis of our correlation between oxidative gene expression signature and OS unveiled that the behavior of modulated genes was different among the cancers examined, with the exception of two genes involved in ROS metabolism, such as FoxM1 and TXNRD1, found as statistically significantly high in poor prognosis patients in four out of six of the tumor types analyzed (Figures 3 and 4). The gene discussed is TXNRD1; the disease is cancer.