Given that eNOS-derived NO induces myofibril relaxation, which is considered important in protection against septic myocardial dysfunction [24, 25] and that eNOS-derived NO represents one of the most important protective molecule that fights a wide range of cardiovascular disease resulting from fibrosis to oxidative stress [26], the properties of BDNF (e.g., enhancing calcium cycling and increasing NO) provide a clue that BDNF may protect the heart against septic cardiac dysfunction by increasing NO and the subsequent reduction of oxidative stress. The gene discussed is BDNF; the disease is cardiovascular disorder.