In the current study, although we provided evidences that BDNF conferred cardioprotective effects against cardiac hypertrophy in sepsis rats was mainly through reducing cardiomyocytes apoptosis, we could not rule out the possibility that other types of cell death such as autophagy and necroptosis may also play roles in these BDNF-induced cardioprotection; further investigation is needed to address the roles of other types of cell death in BDNF-induced cardioprotection. This evidence concerns the gene BDNF and cardiac hypertrophy.