Treatment with curcumin inhibits the PI3K/AKT pathway in various types of cancer cells including breast cancer [17], lung cancer [18], colon cancer [19], renal cancer [20], ovarian carcinoma [21], pancreatic cancer [22], osteosarcoma [23], acute T cell leukemias [24], and liver cancer [25]. Here, AKT1 is linked to osteosarcoma.