LTO1 and cancer: ORAOV1, a highly expressed protein in cancer (Xavier et al., 2012; Togashi et al., 2014; Li et al., 2015), plays an important role in the growth of Hela cells (Jiang et al., 2010), and in oral squamous cell carcinoma (OSCC) as a regulator of cell apoptosis (Jiang et al., 2008), which highlights its relevance to VP2 apoptotic activity.