As an important regulator in the cellular antioxidant system, ORAOV1 in ESCC cells protects the tumor cells from ROS-induced damage by binding to pyrroline-5-carboxylate reductase (PYCR) (Togashi et al., 2014), which can directly scavenge ROS and upregulate the level of antioxidant enzymes (Krishnan et al., 2008). The gene discussed is LTO1; the disease is neoplasm.