However, when normalized to 18S RNA, the reduction in HDAC2 mRNA levels in A549 cells was found to be 72% (P = 0.0001) and 84.6% (P = 0.0001) after infection with PR8 at an MOI of 0.5 and 5.0, respectively (Figure 1A), and a profound 88% (P = 0.0001) and 95% (P = 0.0001) after infection with WSN at an MOI of 0.5 and 5.0, respectively (Figure 1B). The gene discussed is HDAC2; the disease is infection.