We suggest that the increase in non-Vγ9 γδ T cells and IL-10 production by these cells during malarial reinfection in people from endemic areas plays important roles in the acquisition of natural immunity after an increase in memory B cells and malaria-specific antibodies, although IL-10 is also produced by other cells during malaria infection (Freitas do Rosario and Langhorne, 2012; Stanisic et al., 2014). This evidence concerns the gene IL10 and malaria.