Based on accumulating evidence, Davel et al. recently proposed that in normal physiology, the endothelial mineralocorticoid receptor is vasoprotective; however, in the presence of cardiovascular risk factors, such as obesity and diabetes, endothelial mineralocorticoid receptor activation leads to endothelial dysfunction as a result of reduced eNOS activity and NO production, increased oxidative stress via eNOS uncoupling and NOX activation, as well as induced expression of adhesion molecules for inflammatory cells (124). The gene discussed is NOS3; the disease is Obesity.