The phase III study Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction (PARAGON-HF) (NCT01920711) is currently underway, while preliminary data from the PARAMOUNT study have shown a significant reduction of the circulating levels of NT-proBNP (a major prognostic biomarker in HF) after 12 weeks of treatment, and an improvement of both cardiac size and New York Heart Association (NYHA) class at 36 weeks as compared to valsartan (159). Here, NPPB is linked to hydrops fetalis.