Nevertheless, the expression of both TLR7 and TLR9 is up-regulated in the peripheral blood mononuclear cells (PBMC) from the SLE patients, and their levels are correlated with the production of IFN-α (Lyn-Cook et al., 2014), making them potential therapeutic targets of SLE. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.