Interestingly, in a mouse model of dextran sulfate sodium (DSS)-induced colitis, 1A6 could ameliorate inflammation and prevent the progression of the intestine inflammation; however, the blockade of TLR4 signaling by 1A6 could also cause a defect in the mucosal healing during the recovery stage (Ungaro et al., 2009). The gene discussed is TLR4; the disease is colitis.