Cox regression analyses showed that the serum SHI level was an independent indicator of TTR (HR, 3.98; 95% CI, 1.81–8.78; p = 0.001; Table 2) and OS (HR, 4.42; 95% CI, 1.69–11.54; p = 0.002; Table 2) of HBV-HCC patients. Here, TTR is linked to hepatocellular carcinoma.