In multivariate analysis, the SHI was an independent indicator for TTR [Hazard ratio (HR), 2.97; 95% confidence interval (CI): 1.58–5.58; p = 0.001; Table 2] and OS (HR, 2.82; 95% CI: 1.25–6.39; p = 0.013; Table 2) of HBV-HCC patients. This evidence concerns the gene TTR and hepatocellular carcinoma.