ESAM and neoplasm: Furthermore, high HDL may protect against tumor, which modulates inflammatory responses with suppressing chemotactic activity of lymphocytes and monocytes and inhibiting cytokine-induced expression of endothelial cell adhesion molecules, and protecting the integrity of lymphocytes from oxidative damage (Cockerill et al., 2001; Nofer et al., 2002; Tietge et al., 2003; Papageorgiou et al., 2016).