Our data showed that the production of ROS and MDA were increased in the DM-induced diabetic group, which was accompanied by the impairment of SOD activity, while lovastatin considerably reduced the generation of ROS and MDA, and also it up-regulated the activity of SOD, in addition, lovastatin decreased the expression of NOX4 in the DM-induced diabetic group. Here, SOD1 is linked to diabetes mellitus.