Our results showed that compared with NC group, the levels of CD31 and VE-cadherin were decreased, while α-SMA and vimentin were increased in DM group, those were markedly reversed partly by lovastatin, suggesting lovastatin could alleviate hyperglycemic-induced EndMT, our vitro experiments also indicated that lovastatin could suppress high glucose induced EndMT. Here, CDH5 is linked to diabetes mellitus.