EGFR and colorectal carcinoma: For instance, the identification of KRAS mutation at codons 12 and 13 in metastatic CRC predicts the lack of benefit from EGFR-targeted antibodies (Van Cutsem et al., 2011), and for the non-small cell lung cancer patients with EGFR del746_A750 or L858R, they are very responsive to EGFR tyrosine kinase inhibitors (Mok et al., 2009).