BMP-9 promotes liver fibrosis via HSC differentiation, and promotes collagen 1 and fibronectin production (Bi and Ge, 2014; Breitkopf-Heinlein et al., 2017). BMP9 appears to mediate these actions through ALK1/5 (Munoz-Felix et al., 2016). This evidence concerns the gene GDF2 and Hepatic fibrosis.