Both de-phosphorylated and phosphorylated forms of TFEB existed in nuclear compartment (Pe-a Llopis et al., 2011), and the migration of TFEB greatly influenced the function of TFEB, resulting in the facilitation of clearance of abnormal protein deposition in PD and HD (Tsunemi et al., 2012; Decressac and Björklund, 2013). This evidence concerns the gene TFEB and Huntington disease.