Accumulating evidence has demonstrated a crucial role for NTFs in the treatment of neurological diseases after cell transplantation (Isele et al., 2007; Müller et al., 2009; Abbaszadeh et al., 2015), but the role of Neurotrophin-3 (NT-3), an important member of the NTF family, in SCI following with HSC transplantation needs to be explored. This evidence concerns the gene NTF3 and nervous system disorder.