Although a beneficial effect of IFNβ to limit stroke injury remains controversial (Maier et al., 2006; Inacio et al., 2015; Kuo et al., 2016), IFNβ is known to limit inflammatory cytokine expression via IRF2 (Hinkerohe et al., 2005; Buttmann et al., 2007). Here, IRF2 is linked to Stroke.