Previously, a comprehensive genomic study identified several PD risk loci in cerebellum and frontal cortex of PD brains, including PARK16, GPNMB, and STX1B genes, that were associated with differential DNA methylation at proximal CpG sites (International Parkinson’s Disease Genomics Consortium (IPDGC) and Wellcome Trust Case Control Consortium 2 (WTCCC2), 2011). The gene discussed is GPNMB; the disease is Parkinson disease.