CRLF3 and amyotrophic lateral sclerosis: CRLF3 has been implicated with typical cytokine-regulated processes such as cell cycling and cellular morphogenesis (Yang et al., 2009; Hashimoto et al., 2012) and alterations of its expression have been detected in various types of tumors (Dang et al., 2006; Yang et al., 2009) and patients affected by ALS (Cirulli et al., 2015).