Variations of crlf3 sequences have been associated with amyotrophic lateral sclerosis (ALS; Cirulli et al., 2015) and increased CRLF3 content has been detected in various tumor cell lines and freshly isolated tumors (Dang et al., 2006; Yang et al., 2009). This evidence concerns the gene CRLF3 and amyotrophic lateral sclerosis.