The activation of homeodomain-interacting protein kinase 2 (HIPK2) was reported to promote ER-stress-induced cell death via the IRE1α-ASK1-JNK pathway in TDP-43 proteinopathy in both sporadic and C9orf72-related ALS (Lee et al., 2016). The gene discussed is HIPK2; the disease is amyotrophic lateral sclerosis.