Although the IL-23/Th17 axis has been described as the orchestrator of the recruitment and activation of neutrophils and a key player in chronic inflammation and autoimmunity, recent evidence suggests that the effector cytokines Th17 (IL-17 and IL-22) play a crucial role in maintaining mucosal immunity, protecting against extracellular bacteria and fungi. This evidence concerns the gene IL22 and Autoimmunity.