In a selection of 10 clinical cohort studies represented by a total of 1133 NSCLC patients, Shi et al. showed a shorter overall survival in OPN-positive patients compared to that in OPN-negative patients with no significant differences between the Asian and the Caucasian groups, thus suggesting a role for OPN as a prognostic factor for NSCLC [102]. Here, SPP1 is linked to non-small cell lung carcinoma.