In the present study, we measured the serum levels of 10 proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-22, IL-23, sTNF-RI, and sTNF-RII), as well as CRP levels and the ESR, in patients with HS and healthy controls. The gene discussed is IL1B; the disease is histiocytic sarcoma.