When comparing the 4 groups (3 groups of HS patients and 1 control group), statistically significant differences in the levels of IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-23, sTNF-RI, sTNF-RII, and CRP, as well as the ESR, were observed (Figure 1). Here, ESR1 is linked to histiocytic sarcoma.