Thus, to gain more insight into the role of Gr1low monocytes during obesity, we used female mice models, which are associated with major changes in the proportion of Gr1low monocytes in blood: CX3CR1−/− mice; CD11c-hBcl2 mice; and the double genetically modified CX3CR1−/−/CD11c-hBcl2 mice. Here, CX3CR1 is linked to obesity due to melanocortin 4 receptor deficiency.