In addition, the IHC staining and real-time PCR results of COX-2, BCL9, VEGF, CD34, miR-30a-5p and miR-30a-3p in human tissue samples from patients with H. pylori gastritis, H. pylori-related gastric cancer and healthy controls were also in agreement with those findings in vitro and in vivo. The gene discussed is PTGS2; the disease is gastric cancer.