ZFPM2 and congenital diaphragmatic hernia: As mentioned above, mutations in GATA4 and ZFPM2 in CDH patients and mice lead to defects in diaphragm development and CDH (Ackerman et al., 2005; Arrington et al., 2012; Brady et al., 2014; Jay et al., 2007; Longoni et al., 2012, 2014b; Merrell et al., 2015; Yu et al., 2013).