SCN1A and Alzheimer disease: Hypofunction of Nav1.1 has been also observed in other mouse models such as Tg2576, TgCRND8, and BACE1 transgenic mice (Kim et al, 2007; Corbett et al, 2013; Hamm et al, 2017), and the effect of amyloid on Nav1.1 expression and its phenotypic consequences in AD mouse models should continue to be reviewed and validated in future studies.