APP and Alzheimer disease: Of particular note, the amyloid plaques in AppNL‐F mice mainly consisted of pathogenic Aβ1/3pE‐42 (Saido et al, 1995) in a manner similar to the brains of AD patients, whereas the amyloid plaques in APP‐Tg mice were predominately composed of Aβ1–40 and were unphysiologically large, compared to those observed in App knock‐in mice and AD patients.