App knock‐in mice that harbor a third mutation, an E693G Arctic mutation (AppNL‐G‐F), were also generated that makes Aβ more oligomerization/fibrillization‐prone (Cheng et al, 2007; Gessel et al, 2012), and these mice exhibited threefold faster and greater AD pathology and cognitive abnormalities compared with AppNL‐F mice. This evidence concerns the gene APP and Alzheimer disease.